Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Lys-CoA TFA (Lys-coenzyme A) | 98.5% | 25 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). This compound inhibits p300 HAT activity-dependent transcriptional activation and is for research use only.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- Displays greater than 100-fold selectivity for p300 over PCAF
- Inhibits p300 HAT activity-dependent transcriptional activation
- Induces a senescent phenotype in human normal melanocytes
eMolecules 76-05-1 | Trifluoroacetic acid, biochemical grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 662699512
Trifluoroacetic acid, biochemical grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 662699512
Medchemexpress LLC VTP-27999 TFA | 1013937-63-7 | 97.00% | C28H42ClF3N4O7 | 25 MG
VTP-27999 TFA is a potent alkyl amine Renin inhibitor, recognized for its role in addressing hypertension and related end-organ diseases. This compound is primarily utilized in research settings to explore the mechanisms of renin-angiotensin-aldosterone system (RAAS) regulation. Its specific inhibitory action offers a valuable tool for studying cardiovascular conditions and developing novel therapeutic strategies.
- Potent alkyl amine renin inhibitor
- Useful for hypertension research
- Applicable in studies of end-organ diseases
- Supports research on RAAS regulation
- Aids in the development of cardiovascular therapies
Medchemexpress LLC AS-99 TFA | 99.2% | C29H31F6N5O5S2 | 1 ML
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor with anti-leukemic activity. It blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. The compound has an IC50 of 0.79 μM and a Kd of 0.89 μM for ASH1L.
- First-in-class, potent, and selective ASH1L histone methyltransferase inhibitor.
- Exhibits anti-leukemic activity.
- Blocks cell proliferation.
- Induces apoptosis and differentiation.
- Downregulates MLL fusion target genes.
- Reduces leukemia burden in vivo.
- Selective for ASH1L, with no significant inhibition observed at 50 μM on a panel of 20 other histone methyltransferases.
Sigma Aldrich Fine Chemicals Biosciences TRIFLUOROACETIC ACID 100ML
NC3241523 TRIFLUOROACETIC ACID 100ML
Medchemexpress LLC ALX-1393 TFA | 99.8% | 509.45 | 25 MG
ALX-1393 TFA is a selective GlyT2 inhibitor that demonstrates an antinociceptive effect against thermal, mechanical, and chemical stimulations in a rat acute pain model.
- Selective GlyT2 inhibitor
- Exhibits an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model
Medchemexpress LLC Cl2e-SN-38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 25 MG
CL2E-SN38 TFA is a trifluoroacetate salt of an antibody-linked SN-38 conjugate used for antibody-drug conjugate (ADC) research. It acts as a topoisomerase I inhibitor and is supplied as a high-purity solid characterized for in vitro and in vivo formulation.
- Purity: 99.07% (reported on product page)
- Form: trifluoroacetate salt
- Molecular weight: 1855.95
- Chemical formula: C89H117F3N14O26
- Solubility: soluble in DMSO (example: 100 mg/mL); in vivo formulations reported at ≥2.5 mg/mL
- Storage: protect from light; store under nitrogen; in solvent: -80°C for long term
- Intended use: research reagent for ADC development and topoisomerase I inhibition studies
Medchemexpress LLC dTAGV-1 TFA | 2624313-15-9 | 99.9% | C70H91F3N6O16S | 1 MG
dTAGV-1 TFA is a potent and selective PROTAC degrader targeting FKBP12F36V-tagged proteins. It is capable of inducing degradation of FKBP12F36V-Nluc both in vitro in 293FT cells and in vivo in animal models.
- Potent and selective degrader of FKBP12F36V-tagged proteins.
- Induces degradation of FKBP12F36V-Nluc in vivo.
- Effective in 293FT cells.
- Reduces bioluminescent signal in animal models.
Medchemexpress LLC Eda-da tfa | 87156-01-2 | 95.0% | 298.22 | 5 MG
EDA-DA is a N-terminally tagged dipeptide probe used to label Peptidoglycan (PG) of bacteria. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- N-terminally tagged dipeptide probe
- Labels peptidoglycan of bacteria
- Click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Cl2e-SN-38 TFA | 99.5% | 1855.95 | C89H117F3N14O26 | 1 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) linker-payload provided as the trifluoroacetate (TFA) salt. It incorporates SN-38, the active metabolite of irinotecan, and is intended for research use in ADC development and preclinical studies.
- Highly releasable linker-SN-38 conjugate suitable for ADC research.
- Provided as the trifluoroacetate salt to aid handling and formulation.
- Molecular weight 1855.95 and formula C89H117F3N14O26.
- High purity (reported ~99.5%).
- Available in milligram-scale quantities for assay development and conjugation experiments.
Apexbio Technology LLC 2X HyperFusion High-Fidelity Master Mix 10X1ml
2X HyperFusion High-Fidelity Master Mix provides high fidelity strong amplification capability and faster amplification speed for most PCR applications HyperFusion DNA polymerase is composed of a Pyrococcus-like proofreading polymerase fused with a DNA-binding domain Its unique structure which combines a novel Pyrococcus-like enzyme and a domain enhancing synthesis capability increases fidelity and speed Due to its high fidelity HyperFusion DNA polymerase is an ideal choice for molecular cloning or other downstream applications HyperFusion DNA polymerase is among the DNA polymerases with the highest fidelity having a 50-fold lower error rate compared to Taq DNA polymerase and a 6-fold lower error rate than Pyrococcus Furious DNA polymerase HyperFusion DNA polymerase exhibits 5 to 3 polymerase activity and 3 to 5 exonuclease activity It generates blunt-ended PCR products without A-overhangs The extension rate is approximately 15-30 sec per kb (up to 10 kb in length)
Medchemexpress LLC TP-5801 TFA | 99.6% | 641.48 | 5 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with anti-tumor activity.
- TNK1 inhibitor with an IC50 of 1.40 nM.
- Inhibits TNK1-driven, BCR-ABL-driven and IL-3-driven Ba/F3 cell growth.
- Inhibits TNK1-dependent L540 cell growth.
- Demonstrates efficacy in mouse survival models.
- Capable of inhibiting localized tumor growth in vivo.
- For research use only.
Apexbio Technology LLC cyclo(RLsKDK) TFA(Synonyms: cyclo(RLsKDK), Cyclic peptide RLsKDK, ADAM8 inhibitor peptide, Cyclo-Arg-Leu-Ser-Lys-Asp-Lys), 1mg.
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology